德国马克思·普朗克学会实验胚胎学博士后

Postdoc in Epigenetics and Disease : Freiburg, Germany

Employers:

Max Planck Society

Location(s):

Freiburg, Germany

Posted:

March 12, 2010

Expires:

April 30, 2010

Website:

http://www.mpg.de/english/portal/index.html

Job Tag(s):

epigenetics,postdoc,freiburg,molecular biology,europe

Description:

The Max-Planck-Institute of Immunobiology in Freiburg, Germany, invites applications for a

Postdoctoral Position in Epigenetics and Disease

in the Epigenetic Focus (Pospisilik Group) available for an initial two-year appointment with the possibility of extension.

The Pospisilik group is one of the founding groups of the Max Planck Society’s Epigenetic Focus. The position is a unique opportunity to help build a dynamic epigenetic research core in the heart of Europe. Situated at the borders of Germany, France, and Switzerland, Freiburg offers a seemingly limitless, unique and collaborative setting for both culture and research at the highest level. Strong and regular scientific interactions exist between the MPI-Freiburg, the FMI and ETH in Basel, as well as the IGBMC in Strasbourg.

The Pospisilik lab aims to unravel the role of epigenetic mechanisms in the establishment of disease and disease susceptibility. Our primary focus is metabolic disease including diabetes and obesity, and extends to cancer and beyond. Included, are the elucidation of the interplay of histone modifications and chromatin remodelers in the function and development of metabolic tissues (brown and white adipose, liver and muscle) as well as their roles in establishing and maintaining disease tone ie. disease memory. The projects will synergize systems biology and profiling approaches (eg. ChIP-seq, 4C, 5C) with in vivo functional definition by targeted mutation in cells and mice.

The successful candidate will be an independent and motivated team-player with strong communication skills and a strong background in molecular biology and chromatin regulation. Experience with next-generation sequencing, bioinformatics, ES/iPS cells and/or gene-targeting are considered fortes. The successful candidate will be encouraged to apply for external funding.

Selected papers:

Pospisilik JA, Schramek D, Cronin S, Nehme N, Orthofer M, Neely GG, Todoric J, Bayer M, Dietzl G, Funovics M, Wagner O, Prager G, Ferrandon D, Esterbauer HE, Penninger JM. Drosophila whole genome mining reveals Hedgehog-signaling as a key regulator of brown/white adipose cell fate. Cell._140(1):148-60 (2010)

Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia C, Keene AC, Alayari NN, Elling U, Berger C, Novatchkova M, Koglgruber R, Nishina H, Isobe M, Pospisilik JA, Imai Y, Knoblich JA, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Bodmer R, Penninger JM. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. (in press)

Pospisilik JA, Knauf C, Joza N, Cani P, Nakashima T, Sarao R, Neely G, Kroemer G, KahnCR, Koslov A, Esterbauer H, Burcelin R, and Penninger JM. Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes. Cell.131: 476-91 (2007)

Salaries are internationally competitive, in accordance with postdoctoral fellowships of the Max-Planck-Society and commensurate with experience. A childcare facility is directly attached to the MPI of Immunobiology. Handicapped applicants with equal qualifications will be given preferential treatment. The Max Planck Society seeks to increase the number of women in areas, where they are underrepresented, and therefore explicitly encourages women to apply.

Contact:

Candidates should send their Applications (cover letter, CV and contact details of 3 references) indicating the reference number 030310 via e-mail toweigold@immunbio.mpg.deor to the Max-Planck-Institute of Immunobiology, Personnel Department, Stübeweg 51, 79108 Freiburg.