英国剑桥大学蛋白结晶研究博士后岗位
日期：2008-04-21
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InstitutionUniversity of CambridgePositionTwo Post-Doctoral Research Associates & Two Research AssistantsLocationCambridge UKDate PostedApril 18th 2008Date ExpiresMay 9th 2008Tagspostdoctoral rese ...
Institution
University of Cambridge
Position
Two Post-Doctoral Research Associates & Two Research Assistants
Location
Cambridge, UK
Date Posted
April 18th 2008
Date Expires
May 9th 2008
Tags
postdoctoral research associates, research assistants, Cambridge, and uk
Description
Two post-doctoral research associates, funded by an EU FP7 Programme,are available immediately for 3 years to work on structure/function ofthe polypeptide growth factor HGF/SF and its receptor MET and thedevelopment of MET therapeutics (see Nat Mol Cell Biol 4:915-25, 2003for an overview of the signalling system and its relevance to cancer therapy).
SFMET1 and SFMET2: These post-doctoral research associate positions arefor protein crystallographers to work on: – the crystallisation andstructure solution of fragments of HGF/SF with antagonistic activity incomplex with MET (SFMET1) and, – crystallisation and structure solutionof HGF/SF-MET complexes (SFMET2) (see PNAS 103:4046-4051, 2006 for adescription of the complexes under study). A strong background proteincrystallography is essential for these positions. Experience withprotein expression and purification and/or site-directed mutagenesis isalso expected.
SFMET3: This research assistant position is for three years and is for abacterial/phage geneticist to work on affinity maturation of fragmentsof HGF/SF with antagonistic activity (PNAS 104:14592-7, 2007 and JMB377:616-22, 2008). The work will involve phage display, mutagenesis andselection of phage variants and their physico-chemical and biological
characterisation.
SFMET4: This is a research assistant position for 12 months in the firstinstance for a biophysicist working on the interaction between smallmolecules and the MET ectodomain. A background and previous experiencein physical chemistry is essential and is expected to cover isothermalcalorimetry, mass spectrometry and surface plasmon resonance.
Contact
The posts will be based either at the University Department of Oncology(at the MRC Centre in Cambridge) or at the University Department of Biochemistry.
Informal enquiries should be directed to Dr Ermanno Gherardi onegherard@mrc-lmb.cam.ac.uk or Sir Tom Blundell on tom@cryst.bioc.cam.ac.uk
Completed applications consisting of a PD18 form (downloadable fromhttp://www.admin.cam.ac.uk/offices/hr/forms/pd18/), CV includingresearch summary, and the names and addresses of two referees should besent to Judith Nial via email: jln23@cam.ac.uk or to Department ofOncology, Hutchison / MRC Research Centre, Box 197, Hills Road,Cambridge, CB2 0XZ.
Research Associate Salaries: £25,134 – £32,796.
Research Assistant Salaries: £21,682 – £24,403.
Please state clearly which post you are applying for.
The University values diversity and is committed to equality of opportunity.
University of Cambridge
Position
Two Post-Doctoral Research Associates & Two Research Assistants
Location
Cambridge, UK
Date Posted
April 18th 2008
Date Expires
May 9th 2008
Tags
postdoctoral research associates, research assistants, Cambridge, and uk
Description
Two post-doctoral research associates, funded by an EU FP7 Programme,are available immediately for 3 years to work on structure/function ofthe polypeptide growth factor HGF/SF and its receptor MET and thedevelopment of MET therapeutics (see Nat Mol Cell Biol 4:915-25, 2003for an overview of the signalling system and its relevance to cancer therapy).
SFMET1 and SFMET2: These post-doctoral research associate positions arefor protein crystallographers to work on: – the crystallisation andstructure solution of fragments of HGF/SF with antagonistic activity incomplex with MET (SFMET1) and, – crystallisation and structure solutionof HGF/SF-MET complexes (SFMET2) (see PNAS 103:4046-4051, 2006 for adescription of the complexes under study). A strong background proteincrystallography is essential for these positions. Experience withprotein expression and purification and/or site-directed mutagenesis isalso expected.
SFMET3: This research assistant position is for three years and is for abacterial/phage geneticist to work on affinity maturation of fragmentsof HGF/SF with antagonistic activity (PNAS 104:14592-7, 2007 and JMB377:616-22, 2008). The work will involve phage display, mutagenesis andselection of phage variants and their physico-chemical and biological
characterisation.
SFMET4: This is a research assistant position for 12 months in the firstinstance for a biophysicist working on the interaction between smallmolecules and the MET ectodomain. A background and previous experiencein physical chemistry is essential and is expected to cover isothermalcalorimetry, mass spectrometry and surface plasmon resonance.
Contact
The posts will be based either at the University Department of Oncology(at the MRC Centre in Cambridge) or at the University Department of Biochemistry.
Informal enquiries should be directed to Dr Ermanno Gherardi onegherard@mrc-lmb.cam.ac.uk or Sir Tom Blundell on tom@cryst.bioc.cam.ac.uk
Completed applications consisting of a PD18 form (downloadable fromhttp://www.admin.cam.ac.uk/offices/hr/forms/pd18/), CV includingresearch summary, and the names and addresses of two referees should besent to Judith Nial via email: jln23@cam.ac.uk or to Department ofOncology, Hutchison / MRC Research Centre, Box 197, Hills Road,Cambridge, CB2 0XZ.
Research Associate Salaries: £25,134 – £32,796.
Research Assistant Salaries: £21,682 – £24,403.
Please state clearly which post you are applying for.
The University values diversity and is committed to equality of opportunity.
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