洛杉矶Nevada肿瘤研究所肿瘤干细胞研究博士后岗位

Institution

Nevada Cancer Institute (http://www.nevadacancerinstit...)

Position

Postdoctoral Position

Location

Las Vegas, NV

Date Posted

Nov 14th 2007

Description

Two federal-funded postdoctoral positions are available immediately for highly motivated individuals at the Nevada Cancer Institute in Las Vegas. We are studying how pluripotency of human embryonic and adult stem cells maintains and how its deregulation may result in cancer stem cells with a focus on leukemic stem cells. A Ph.D. degree with strong background in molecular biology, biochemistry, and tissue culture is high desirable. Prior experience in hematopoietic stem cells or human embryonic stem cells is required.

Recent publications from the laboratory:

1. L Chai, Yang J, Di C, Cui W, Lai R, and Ma Y. Transcriptional activation of the SALL1 by the human SIX1 domain. 2006, J. Biol. Chem. 14;281(28):18918-26.

2. Ma Y, Wei C, Yang J, Qu J, Di C , Amin HM, Lai R, Ritz J, Krause DS, and L Chai. SALL4, a novel oncogene, is constitutively expressed in acute myeloid leukemia (AML) and is sufficient to induce AML in transgenic mice. 2006, Blood, Oct 15;108(8):2726-35.

3. Zhang J, Tam W, Tong GQ, Wu Q, Chan BS, Lou Y, Yang J, Ma Y, Chai L, Ng H, Lufkin T, Robson P and B Lim. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. 2006, Nature Cell Biology, Oct;8(10): 1114.

4. Yang J, Chai L, Liu F, Flink L,Pei L, Siberstain L, Amin, HM, Ward D, and Ma Y. Bmi-1 is a SALL4 Target Gene for SALL4 in Hematopoietic and Leukemic Cells. 2007, Proc. Natl. Acad. Sci. USA. 2007;104:10494-10499.

Contact

Please send curriculum vitae and names and contact information of three references to: Yupo Ma, MD, PhD, Chief of Hematopathology at Nevada Cancer Institute,yma@nvcancer.org