英国医学理事会染色质生物化学博士后职位

Applications are invited for a postdoctoral research position within the Chromatin Biochemistry Group at theMRC-Clinical Sciences Centre. We are looking for a highly motivated individual with a strong background in chromatin biology. The successful candidate will have the opportunity to investigate the molecular mechanisms of chromatin regulation byDNAand histone modification patterns.

purpose:
The Chromatin Biochemistry Group at theMRC-CSCis headed by Dr Till Bartke and aims to understand how combinations ofDNAand histone modifications regulate the activity of chromatin. We are particularly interested in the molecular mechanisms that underlie epigenetic gene regulation events during tumour formation and differentiation processes. We employ the tools of chemical biology, biochemistry and proteomics in conjunction with tissue culture and chromatin techniques in order to identify and study chromatin-associated protein complexes that can recogniseDNAand histone modification patterns. Recent publications that outline the future research directions are: Bartke et al., 2010 (Cell143: 470-484); Bartke et al., 2011 (Cell Cycle10, 182).

Candidates should have a PhD in Molecular Biology (or equivalent) with a strong background in chromatin biology. Experience in using genomic technologies (ChIP/ChIPseq andRNAsequencing, microarrays) for epigenetic and gene expression profiling of tissue culture cells is essential. The post holder will also be familiar with molecular biology and biochemical techniques (molecular cloning, expression and purification of recombinant proteins) and be willing to engage in internal and external collaborations.

The Chromatin Biochemistry Group is a newly established group at theCSCand as such offers start-up spirit and the opportunity to work on cutting-edge inter-disciplinary projects. TheCSCprovides an excellent research environment in an international and interactive atmosphere. We are looking for a highly motivated and committed individual with clear goals, a proactive and flexible attitude to work, and the will to learn new concepts and technologies to join our team.

Direct informal enquiries to Dr Till Bartke (till.bartke@csc.mrc.ac.uk)

Applications are handled by theRCUKShared Services Centre; to apply please visit our job board athttps://ext.ssc.rcuk.ac.ukand complete an online application form. Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003, Please quote reference number IRC28491.

Closing date for all completed applications is 5 October 2011.

‘The Medical Research Council is an Equal Opportunities Employer’
Final appointment will be subject to pre-employment screening.